Innovation flourishes when grounded in human values. This keynote introduces the THRIVE Framework: tenacity, honesty, relatability, integrity, vulnerability, and empathy as a foundation for driving innovation and collaboration in education and the world of work. By focusing on building meaningful relationships, the framework fosters an educational culture where students feel supported, educators feel empowered, and innovation becomes a natural outcome of collaboration. This keynote explores how combining these values with innovative practices can transform education, fostering environments that inspire growth, creativity, and connection, and preparing everyone for today and the future of work. Attendees will be challenged to rethink how they approach innovation, how to prepare all students regardless of grade level or content area, and walk away with actionable insights on how to use these values to create equitable and inclusive learning environments that prepare all students to thrive.